KIRA-7


Catalog No. Size PriceQuantity
M24183-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect.

Product information

CAS Number: 1937235-76-1

Molecular Weight: 466.51

Formula: C27H23FN6O

Chemical Name: 3-{4-[8-amino-3-(1-methylcyclopropyl)imidazo[1,5-a]pyrazin-1-yl]naphthalen-1-yl}-1-(3-fluorophenyl)urea

Smiles: CC1(CC1)C1=NC(=C2C(N)=NC=CN21)C1=CC=C(NC(=O)NC2=CC(F)=CC=C2)C2=CC=CC=C12

InChiKey: BMEJPYIGRYVVEF-UHFFFAOYSA-N

InChi: InChI=1S/C27H23FN6O/c1-27(11-12-27)25-33-22(23-24(29)30-13-14-34(23)25)20-9-10-21(19-8-3-2-7-18(19)20)32-26(35)31-17-6-4-5-16(28)15-17/h2-10,13-15H,11-12H2,1H3,(H2,29,30)(H2,31,32,35)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

KIRA-7 can inhibit XBP1 splicing in the alveolar epithelial cell line MLE12.

In Vivo:

KIRA-7 (5 mg/kg; intraperitoneal injection; daily for 14 days; C57BL6 mice) treatment results in decreased spliced XBP1 and ATF4, compared to bleomycin exposed mice treated with vehicle. Likewise, mRNA levels of BiP and CHOP are significantly elevated after Bleomycin exposure, and treatment of Bleomycin-exposed mice with KIRA-7 decreased these levels. mRNA levels of collagen 1A1 and fibronectin are both significantly decreased by KIRA-7 treatment.

Products are for research use only. Not for human use.

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