PF-06928215


Catalog No. Size PriceQuantity
M24219-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μΜ. PF-06928215 has a high binding affinity of 0.2 μM (Kd).

Product information

CAS Number: 2378173-15-8

Molecular Weight: 380.40

Formula: C20H20N4O4

Chemical Name: (1R,2S)-2-{7-oxo-5-phenyl-1H,7H-pyrazolo[1,5-a]pyrimidine-3-amido}cyclohexane-1-carboxylic acid

Smiles: OC(=O)[C@@H]1CCCC[C@@H]1NC(=O)C1=CNN2C1=NC(=CC2=O)C1C=CC=CC=1

InChiKey: WGQGCLHXUPGUSZ-HIFRSBDPSA-N

InChi: InChI=1S/C20H20N4O4/c25-17-10-16(12-6-2-1-3-7-12)22-18-14(11-21-24(17)18)19(26)23-15-9-5-4-8-13(15)20(27)28/h1-3,6-7,10-11,13,15,21H,4-5,8-9H2,(H,23,26)(H,27,28)/t13-,15+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 33.33 mg/mL (87.62 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PF-06928215 displays no activity in cellular cGAS assays measuring dsDNA-induced IFN-beta expression.

Products are for research use only. Not for human use.

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