SQ609


Catalog No. Size PriceQuantity
M24264-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SQ609 is a lead compound from a library of dipiperidines. SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells. SQ609 displays a potent antitubercular activity .

Product information

CAS Number: 627052-25-9

Molecular Weight: 346.55

Formula: C22H38N2O

Chemical Name: 1-({1-[(adamantan-1-yl)methyl]piperidin-4-yl}methyl)piperidin-4-ol

Smiles: OC1CCN(CC2CCN(CC34CC5CC(C3)CC(C4)C5)CC2)CC1

InChiKey: YUBKDPOCUHUSLW-UHFFFAOYSA-N

InChi: InChI=1S/C22H38N2O/c25-21-3-7-23(8-4-21)15-17-1-5-24(6-2-17)16-22-12-18-9-19(13-22)11-20(10-18)14-22/h17-21,25H,1-16H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 6.67 mg/mL (19.25 mM; ultrasonic and warming and heat to 60°C).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

In Mtb-infected macrophages in vitro, SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells.

In Vivo:

SQ609 (10 mg/kg; intravenous injection) completely prevents weight loss in the Mtb-infected animals and prolongs the therapeutic effect following drug withdrawal for another 10-15 days.

Products are for research use only. Not for human use.

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