ASP1126


Catalog No. Size PriceQuantity
M24308-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile.

Product information

CAS Number: 1228580-11-7

Molecular Weight: 581.93

Formula: C26H26ClF6NO5

Chemical Name: 1-[(7-{[4-(2,2,2-trifluoroethoxy)-3-(trifluoromethyl)phenyl]methoxy}-2H-chromen-3-yl)methyl]piperidine-4-carboxylic acid hydrochloride

Smiles: Cl.OC(=O)C1CCN(CC2COC3=CC(=CC=C3C=2)OCC2=CC(=C(C=C2)OCC(F)(F)F)C(F)(F)F)CC1

InChiKey: LLYLBEQEAUKJEK-UHFFFAOYSA-N

InChi: InChI=1S/C26H25F6NO5.ClH/c27-25(28,29)15-38-22-4-1-16(10-21(22)26(30,31)32)13-36-20-3-2-19-9-17(14-37-23(19)11-20)12-33-7-5-18(6-8-33)24(34)35;/h1-4,9-11,18H,5-8,12-15H2,(H,34,35);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

ASP1126 (1 and 5 mg/kg, orally once daily for 14 days) significantly prolongs allograft survival. ASP1126 in combination with 0.02 mg/kg tacrolimus notably improves graft survival time.

Products are for research use only. Not for human use.

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