JAK-2/3-IN-1


Catalog No. Size PriceQuantity
M24504-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

JAK-2/3-IN-1 is a potent JAK-2 and JAK-3 inhibitor extracted from patent US8163732B2, compound 46, has Kis of <250 nM for both isoforms.

Product information

CAS Number: 1036241-36-7

Molecular Weight: 345.78

Formula: C20H12ClN3O

Chemical Name: 3-chloro-4-{8,12,14-triazatetracyclo[8.6.1.0²,⁷.0¹³,¹⁷]heptadeca-1(17),2,4,6,8,10,12,15-octaen-9-yl}phenol

Smiles: OC1=CC(Cl)=C(C=C1)C1=NC2=CC=CC=C2C2C=CNC3=NC=C1C=23

InChiKey: JBHMPWHPXOOFNL-UHFFFAOYSA-N

InChi: InChI=1S/C20H12ClN3O/c21-16-9-11(25)5-6-14(16)19-15-10-23-20-18(15)13(7-8-22-20)12-3-1-2-4-17(12)24-19/h1-10,25H,(H,22,23)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

The Janus kinases (JAK) are a family of tyrosine kinases that play a critical role in cytokine signaling. The family consists of JAK-1, JAK-2, JAK-3 and TYK-2, and the down-stream substrates of this family of kinases include the signal transducer and activator of transcription (STAT) proteins. JAK/STAT signaling has been implicated in the mediation of many abnormal immune responses, such as allergies and asthma; autoimmune diseases; as well as in solid and hematologic malignancies.

Products are for research use only. Not for human use.

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