Description
FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist.
Product information
CAS Number: 903895-98-7
Molecular Weight: 384.86
Formula: C20H21ClN4O2
Chemical Name: 1-(4-chlorophenyl)-3-[1-methyl-3-oxo-2-phenyl-5-(propan-2-yl)-2,3-dihydro-1H-pyrazol-4-yl]urea
Smiles: CN1C(C(C)C)=C(NC(=O)NC2C=CC(Cl)=CC=2)C(=O)N1C1C=CC=CC=1
InChiKey: PAEBEUZTAPIOIO-UHFFFAOYSA-N
InChi: InChI=1S/C20H21ClN4O2/c1-13(2)18-17(23-20(27)22-15-11-9-14(21)10-12-15)19(26)25(24(18)3)16-7-5-4-6-8-16/h4-13H,1-3H3,(H2,22,23,27)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 125 mg/mL (324.79 mM; Need ultrasonic). H2O : < 0.1 mg/mL (insoluble).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
FPR Agonist 43 (10-5-107 nM) is actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells. FPR Agonist 43 is also active in the GTPγ binding assay (IC50=207±51 nM). FPR1 is the preferred receptor for FPR Agonist 43 in in both human neutrophils and possibly also in mouse cells.
Products are for research use only. Not for human use.
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