Description
Desthiobiotin-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Product information
CAS Number: 1951424-89-7
Molecular Weight: 427.53
Formula: C21H37N3O6
Chemical Name: 6-[(4R,5S)-5-methyl-2-oxoimidazolidin-4-yl]-N-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)hexanamide
Smiles: C[C@@H]1NC(=O)N[C@@H]1CCCCCC(=O)NCCOCCOCCOCCOCC#C
InChiKey: CQSNBVBVAYQBHF-RBUKOAKNSA-N
InChi: InChI=1S/C21H37N3O6/c1-3-10-27-12-14-29-16-17-30-15-13-28-11-9-22-20(25)8-6-4-5-7-19-18(2)23-21(26)24-19/h1,18-19H,4-17H2,2H3,(H,22,25)(H2,23,24,26)/t18-,19+/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Products are for research use only. Not for human use.
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