3-Hydroxy Midostaurin

3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412.

Product information

CAS Number: 179237-49-1

Molecular Weight: 600.66

Formula: C36H32N4O5

Chemical Name: N-[(2R,4S,5S,7R)-17-hydroxy-5-methoxy-7-methyl-19-oxo-30-oxa-1,8,18-triazaoctacyclo[13.12.2.1²,⁷.0⁸,²⁹.0⁹,¹⁴.0¹⁶,²⁰.0²¹,²⁸.0²²,²⁷]triaconta-9,11,13,15(29),16(20),21(28),22,24,26-nonaen-4-yl]-N-methylbenzamide

Smiles: CN([C@H]1C[C@H]2O[C@](C)(C[C@@H]1OC)N1C3=C(C4C(O)NC(=O)C=4C4=C3N2C2=CC=CC=C24)C2=CC=CC=C12)C(=O)C1C=CC=CC=1

InChiKey: WMQSFYBLPAXEDG-VBRPBTBPSA-N

InChi: InChI=1S/C36H32N4O5/c1-36-18-25(44-3)24(38(2)35(43)19-11-5-4-6-12-19)17-26(45-36)39-22-15-9-7-13-20(22)27-29-30(34(42)37-33(29)41)28-21-14-8-10-16-23(21)40(36)32(28)31(27)39/h4-16,24-26,34,42H,17-18H2,1-3H3,(H,37,41)/t24-,25-,26+,34?,36+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM.

Products are for research use only. Not for human use.