Description
JF669, SE, a red fluorescent dye, can be directly reacted with the available thiol-containing HaloTag ligand under mild conditions (DIEA, DMF) to afford a JF669−HaloTag ligand in a single step (Ex = 669 nm; Em = 682 nm).
Product information
CAS Number: 2127150-20-1
Molecular Weight: 693.76
Formula: C34H30F3N3O6SSi
Chemical Name: 1-[13-(azetidin-1-yl)-9-[2-carboxylato-5-({2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}sulfanyl)-3,4,6-trifluorophenyl]-2,2-dimethyl-2-silatricyclo[8.4.0.0³,⁸]tetradeca-1(14),3,6,8,10,12-hexaen-5-ylidene]-1λ⁵-azetidin-1-ylium
Smiles: C[Si]1(C)C2=CC(C=CC2=C(C2=C(C([O-])=O)C(F)=C(F)C(SCC(=O)ON3C(=O)CCC3=O)=C2F)C2=CC=C(C=C12)N1CCC1)=[N+]1CCC1
InChiKey: QFHKALIQFJQJKE-UHFFFAOYSA-N
InChi: InChI=1S/C34H30F3N3O6SSi/c1-48(2)22-15-18(38-11-3-12-38)5-7-20(22)27(21-8-6-19(16-23(21)48)39-13-4-14-39)28-29(34(44)45)30(35)32(37)33(31(28)36)47-17-26(43)46-40-24(41)9-10-25(40)42/h5-8,15-16H,3-4,9-14,17H2,1-2H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
JF669 undergoes rapid conversion to thioether product (<5 min to completion) in organic solvents, where the dye predominantly adopts the closed form. JF669 displays comparatively excellent photostability, retaining 97% fluorescence after the same number of cycles.
Products are for research use only. Not for human use.
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