8-NH2-ATP


Catalog No. Size PriceQuantity
M24929-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

8-NH2-ATP, an inactive form of ATP, is produced by 8-NH2-Ado. 8-NH2-Ado is reported to be potent as shown by induction of apoptosis-related cleavage of poly (ADP-ribose) polymerase.

Product information

CAS Number: 35874-49-8

Molecular Weight: 522.20

Formula: C10H17N6O13P3

Chemical Name: ({[({[(2R,3S,4R,5R)-5-(6,8-diamino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid

Smiles: NC1=NC2=C(N=CN=C2N)N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O

InChiKey: FRQGDEVDOCHMCQ-UUOKFMHZSA-N

InChi: InChI=1S/C10H17N6O13P3/c11-7-4-8(14-2-13-7)16(10(12)15-4)9-6(18)5(17)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,15)(H,22,23)(H,24,25)(H2,11,13,14)(H2,19,20,21)/t3-,5-,6-,9-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

The extensive cellular accumulation of 8-NH2-ATP has an inhibitory effect on both RNA and DNA synthesis in both glucocorticoid-sensitive and glucocorticoid-resistant myeloma cell lines.

Products are for research use only. Not for human use.

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