Description
FD-1080 is a fluorophore with both excitation and emission in the NIR-II region (Ex=1064 nm, Em=1080 nm). FD-1080 can be used for in vivo imaging.
Product information
CAS Number: 1151666-58-8
Molecular Weight: 765.31
Formula: C40H38ClN2NaO6S2
Chemical Name: sodium 3-{2-[(3E)-2-chloro-3-{2-[(3E)-2-(4-sulfonatobutyl)-2-azatricyclo[6.3.1.0⁴,¹²]dodeca-1(12),4,6,8,10-pentaen-3-ylidene]ethylidene}cyclohex-1-en-1-yl]ethenyl}-2-(4-sulfonatobutyl)-2-azatricyclo[6.3.1.0⁴,¹²]dodeca-1(11),2,4(12),5,7,9-hexaen-2-ium
Smiles: [Na+].[O-]S(=O)(=O)CCCC[N+]1C2=CC=CC3=CC=CC(=C32)C=1C=CC1CCC/C(=C\C=C2/C3=CC=CC4=CC=CC(=C43)N/2CCCCS([O-])(=O)=O)/C=1Cl |t:23|
InChiKey: UUIDRCSEPATAJK-UHFFFAOYSA-M
InChi: InChI=1S/C40H39ClN2O6S2.Na/c41-40-30(20-22-34-32-16-6-10-28-12-8-18-36(38(28)32)42(34)24-1-3-26-50(44,45)46)14-5-15-31(40)21-23-35-33-17-7-11-29-13-9-19-37(39(29)33)43(35)25-2-4-27-51(47,48)49;/h6-13,16-23H,1-5,14-15,24-27H2,(H-,44,45,46,47,48,49);/q;+1/p-1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
FD-1080 shows superior photostability under the continuous laser irradiation. The quantum yield of FD-1080 is 0.31%, and can be increased to 5.94% after combining with fetal bovine serum (FBS) to form FD-1080-FBS complexes.
In Vivo:
The 1064 nm NIR-II excitation of FD-1080 is demonstrated with the high tissue penetration depth and superior imaging resolution compared to NIR excitation from 650 nm to 980 nm. Deeptissue and high-resolution in vivo imaging for the left hindlimb vasculature, abdomen, and brain vessels was realized, allowing penetration through intact skin, tissue, and skull. FD-1080 also quantifying the respiratory rate based on the dynamic imaging of respiratory craniocaudal motion of the liver for the awake and anaesthetized mouse.
Products are for research use only. Not for human use.
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