Description
Fluorescein-PEG6-bis-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Product information
CAS Number: 2055105-59-2
Molecular Weight: 938.95
Formula: C44H50N4O17S
Chemical Name: 2,5-dioxopyrrolidin-1-yl 1-({[4-(3,6-dihydroxy-9H-xanthen-9-yl)-3-{[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl}phenyl]carbamothioyl}amino)-3,6,9,12,15,18-hexaoxahenicosan-21-oate
Smiles: OC1=CC2OC3=CC(O)=CC=C3C(C3=CC=C(C=C3C(=O)ON3C(=O)CCC3=O)NC(=S)NCCOCCOCCOCCOCCOCCOCCC(=O)ON3C(=O)CCC3=O)C=2C=C1
InChiKey: RFQSEQWGGWBICF-UHFFFAOYSA-N
InChi: InChI=1S/C44H50N4O17S/c49-29-2-5-32-35(26-29)63-36-27-30(50)3-6-33(36)42(32)31-4-1-28(25-34(31)43(56)65-48-39(53)9-10-40(48)54)46-44(66)45-12-14-58-16-18-60-20-22-62-24-23-61-21-19-59-17-15-57-13-11-41(55)64-47-37(51)7-8-38(47)52/h1-6,25-27,42,49-50H,7-24H2,(H2,45,46,66)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Products are for research use only. Not for human use.
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