Description
DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC50 of 30 nM.
Product information
CAS Number: 351353-48-5
Molecular Weight: 378.44
Formula: C21H18N2O3S
Chemical Name: 2,6-dimethoxy-4-[4-phenyl-5-(thiophen-2-yl)-1H-imidazol-2-yl]phenol
Smiles: COC1=CC(=CC(OC)=C1O)C1NC(=C(N=1)C1C=CC=CC=1)C1=CC=CS1
InChiKey: JMXVHYPSBANVAQ-UHFFFAOYSA-N
InChi: InChI=1S/C21H18N2O3S/c1-25-15-11-14(12-16(26-2)20(15)24)21-22-18(13-7-4-3-5-8-13)19(23-21)17-9-6-10-27-17/h3-12,24H,1-2H3,(H,22,23)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
DPTIP blocks EV secretion in a dose dependent manner (0.03-30 μM), and at 30 μM, this compound could decrease exosome release by 50% in astrocytes.
In Vivo:
DPTIP potently (10 mg/kg IP) inhibits IL-1β-induced astrocyte-derived EV release.
Products are for research use only. Not for human use.
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