Folate-PEG3-alkyne


Catalog No. Size PriceQuantity
M25441-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Folate-PEG3-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 1245285-73-7

Molecular Weight: 610.62

Formula: C28H34N8O8

Chemical Name: (2S)-2-[(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]-4-[(2-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}ethyl)carbamoyl]butanoic acid

Smiles: C#CCOCCOCCOCCNC(=O)CC[C@H](NC(=O)C1C=CC(=CC=1)NCC1=CN=C2N=C(N)NC(=O)C2=N1)C(O)=O

InChiKey: BTQOUUGJBSCVDT-NRFANRHFSA-N

InChi: InChI=1S/C28H34N8O8/c1-2-10-42-12-14-44-15-13-43-11-9-30-22(37)8-7-21(27(40)41)34-25(38)18-3-5-19(6-4-18)31-16-20-17-32-24-23(33-20)26(39)36-28(29)35-24/h1,3-6,17,21,31H,7-16H2,(H,30,37)(H,34,38)(H,40,41)(H3,29,32,35,36,39)/t21-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins

Products are for research use only. Not for human use.

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