Description
DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML). DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs).
Product information
CAS Number: 1394079-41-4
Molecular Weight: 942.13
Formula: C53H59N5O9S
Chemical Name: (11S)-5-methoxy-6-{[3-({[(11S)-5-methoxy-2-oxo-1,9-diazatetracyclo[9.7.0.0³,⁸.0¹³,¹⁸]octadeca-3(8),4,6,13,15,17-hexaen-6-yl]oxy}methyl)-5-(13-methyl-13-sulfanyl-2,5,8-trioxa-11-azatetradecan-11-yl)phenyl]methoxy}-1,9-diazatetracyclo[9.7.0.0³,⁸.0¹³,¹⁸]octadeca-3(8),4,6,9,13,15,17-heptaen-2-one
Smiles: COCCOCCOCCN(CC(C)(C)S)C1=CC(COC2=CC3N=C[C@@H]4CC5=CC=CC=C5N4C(=O)C=3C=C2OC)=CC(COC2=CC3NC[C@@H]4CC5=CC=CC=C5N4C(=O)C=3C=C2OC)=C1
InChiKey: DOKWDOLZCMETIJ-ZAQUEYBZSA-N
InChi: InChI=1S/C53H59N5O9S/c1-53(2,68)33-56(14-15-64-18-19-65-17-16-61-3)38-21-34(31-66-49-27-43-41(25-47(49)62-4)51(59)57-39(29-54-43)23-36-10-6-8-12-45(36)57)20-35(22-38)32-67-50-28-44-42(26-48(50)63-5)52(60)58-40(30-55-44)24-37-11-7-9-13-46(37)58/h6-13,20-22,25-29,39-40,55,68H,14-19,23-24,30-33H2,1-5H3/t39-,40-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
DGN462 is a member of the DNA-alkylating indolinobenzodiazepine pseudodimers (IGNs) class.
Products are for research use only. Not for human use.
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