Isochondrodendrine


Catalog No. Size PriceQuantity
M25646-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Isochondrodendrine ( Isochondrodendrin) is a class of bisbenzylisoquinoline alkaloid isolated from Isolona ghesquiereina. Isochondodendrine has strong antiplasmodial activity against Plasmodium falciparum.

Product information

CAS Number: 477-62-3

Molecular Weight: 594.70

Formula: C36H38N2O6

Chemical Name: (11R,26R)-5,20-dimethoxy-10,25-dimethyl-2,17-dioxa-10,25-diazaheptacyclo[26.2.2.2¹³,¹⁶.1³,⁷.1¹⁸,²².0¹¹,³⁶.0²⁶,³³]hexatriaconta-1(30),3(36),4,6,13,15,18(33),19,21,28,31,34-dodecaene-4,19-diol

Smiles: CN1CCC2=CC(OC)=C(O)C3OC4C=CC(C[C@@H]5C6=C(OC7C=CC(C[C@@H]1C2=3)=CC=7)C(O)=C(C=C6CCN5C)OC)=CC=4

InChiKey: XIOGHHPVBVXQIV-VSGBNLITSA-N

InChi: InChI=1S/C36H38N2O6/c1-37-15-13-23-19-29(41-3)33(39)35-31(23)27(37)17-21-5-9-26(10-6-21)44-36-32-24(20-30(42-4)34(36)40)14-16-38(2)28(32)18-22-7-11-25(43-35)12-8-22/h5-12,19-20,27-28,39-40H,13-18H2,1-4H3/t27-,28-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Isochondrodendrine has strong in vitro antiplasmodial activity against the chloroquine resistant strain FMC29 of Plasmodium falciparum. Toxicity observed is 50 to 100 fold greater towards Plasmodium falciparum than cultured L6 cells.

Products are for research use only. Not for human use.

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