Deltasonamide 1


Catalog No. Size PriceQuantity
M25659-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Deltasonamide 1 is a PDE6δ-KRas inhibitor, with a KD of 203 pM.

Product information

CAS Number: 2088485-33-8

Molecular Weight: 647.25

Formula: C30H39ClN6O4S2

Chemical Name: N1-[(4-chlorophenyl)methyl]-N1-cyclopentyl-N4-{[2-(methylamino)pyrimidin-4-yl]methyl}-N4-[(piperidin-4-yl)methyl]benzene-1,4-disulfonamide

Smiles: CNC1N=CC=C(CN(CC2CCNCC2)S(=O)(=O)C2=CC=C(C=C2)S(=O)(=O)N(CC2C=CC(Cl)=CC=2)C2CCCC2)N=1

InChiKey: FWBBCSKXUXMTJY-UHFFFAOYSA-N

InChi: InChI=1S/C30H39ClN6O4S2/c1-32-30-34-19-16-26(35-30)22-36(20-24-14-17-33-18-15-24)42(38,39)28-10-12-29(13-11-28)43(40,41)37(27-4-2-3-5-27)21-23-6-8-25(31)9-7-23/h6-13,16,19,24,27,33H,2-5,14-15,17-18,20-22H2,1H3,(H,32,34,35)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Deltasonamide 1 binds inside the PDE6δ binding pocket, including H-bonds to R61, Q78, E88, and Y149 sidechains, to the carbonyl of C56, two water molecule-mediated H-bonds to the Glu 88 side-chain and the amide proton of M118, two aromatic–p interactions to the indole side-chains of W32 and W90, and one M117-aryl interaction. Deltasonamide 1 migrates slowly but show enhanced apparent permeability from the B to A side suggesting a potential interaction with efflux transporters. Deltasonamides results in a reduced interacting fraction of RheB-PDE6δ. Deltasonamide 1 results in a strongly reduced proliferation, even at submicromolar concentrations in MiaPaCa-2 cells.

Products are for research use only. Not for human use.

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