653-47 hydrochloride


Catalog No. Size PriceQuantity
M25738-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

653-47 hydrochloride, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 hydrochloride is also a very weak CREB inhibitor with IC50 of 26.3 μM.

Product information

CAS Number: 1224567-46-7

Molecular Weight: 407.29

Formula: C20H20Cl2N2O3

Chemical Name: 3-(3-aminopropoxy)-N-(4-chloro-2-hydroxyphenyl)naphthalene-2-carboxamide hydrochloride

Smiles: Cl.NCCCOC1=CC2=CC=CC=C2C=C1C(=O)NC1=CC=C(Cl)C=C1O

InChiKey: HESNWSHDEFHION-UHFFFAOYSA-N

InChi: InChI=1S/C20H19ClN2O3.ClH/c21-15-6-7-17(18(24)12-15)23-20(25)16-10-13-4-1-2-5-14(13)11-19(16)26-9-3-8-22;/h1-2,4-7,10-12,24H,3,8-9,22H2,(H,23,25);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (613.81 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15.

Products are for research use only. Not for human use.

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