Description
BPK-29 is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein (such RBM45 and SNW1) interactions by covalently modifying C274. BPK-29 impairs the anchorage-independent growth of KEAP1-mutant cancer cells.
Product information
CAS Number: 2143467-62-1
Molecular Weight: 470.00
Formula: C26H32ClN3O3
Chemical Name: N-benzyl-2-chloro-N-{1-[4-(morpholin-4-yl)benzoyl]azepan-4-yl}acetamide
Smiles: O=C(C1C=CC(=CC=1)N1CCOCC1)N1CCCC(CC1)N(CC1C=CC=CC=1)C(=O)CCl
InChiKey: ZKWKNYRAPOSUDO-UHFFFAOYSA-N
InChi: InChI=1S/C26H32ClN3O3/c27-19-25(31)30(20-21-5-2-1-3-6-21)24-7-4-13-29(14-12-24)26(32)22-8-10-23(11-9-22)28-15-17-33-18-16-28/h1-3,5-6,8-11,24H,4,7,12-20H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
BPK-29 substantially engages NR0B1 with good overall proteomic selectivity in KEAP1-mutant Non-Small Cell Lung Cancers.
Products are for research use only. Not for human use.
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