BPH-652


Catalog No. Size PriceQuantity
M25918-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

BPH-652 is a S. aureus dehydrosqualene synthase (CrtM) inhibitor, with a Ki of 1.5 nM and an IC50 of 100-300 nM (S. aureus pigment formation).

Product information

CAS Number: 157124-84-0

Molecular Weight: 500.63

Formula: C16H16K3O7PS

Chemical Name: tripotassium 4-(3-phenoxyphenyl)-1-phosphonatobutane-1-sulfonate

Smiles: [K+].[K+].[K+].[O-]P([O-])(=O)C(CCCC1C=C(C=CC=1)OC1C=CC=CC=1)S([O-])(=O)=O

InChiKey: DRADVLDMPYYQDB-UHFFFAOYSA-K

InChi: InChI=1S/C16H19O7PS.3K/c17-24(18,19)16(25(20,21)22)11-5-7-13-6-4-10-15(12-13)23-14-8-2-1-3-9-14;;;/h1-4,6,8-10,12,16H,5,7,11H2,(H2,17,18,19)(H,20,21,22);;;/q;3*+1/p-3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

BPH-652 treatment (0.5 mg twice per day (days −1, 0, 1, and 2), Intraperitoneal injection) significantly lowers S. aureus bacterial counts in the kidneys of the mice than those of the control group (P < 0.001), with 8 of 13 below the detection threshold, versus only 2 of 14 in the control group; on average, this result corresponds to a 98% decrease in surviving bacteria in the treatment group.

Products are for research use only. Not for human use.

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