Description
Purpurin 18 methyl ester, a chlorophyll-a derivative, is a photosensitizer that can be used in photodynamic therapy (PDT). Purpurin 18 methyl ester has photodynamic activity to induce cancer cell death.
Product information
CAS Number: 51744-55-9
Molecular Weight: 578.66
Formula: C34H34N4O5
Chemical Name: methyl 3-[(22S)-17-ethenyl-12-ethyl-3-hydroxy-13,18,22,27-tetramethyl-5-oxo-4-oxa-8,24,25,26-tetraazahexacyclo[19.2.1.1⁶,⁹.1¹¹,¹⁴.1¹⁶,¹⁹.0²,⁷]heptacosa-1(23),2,6(27),7,9,11(26),12,14,16,18,20-undecaen-23-yl]propanoate
Smiles: COC(=O)CCC1[C@H](C)C2=CC3NC(C=C4N=C(C=C5N=C6C(C(=O)OC(O)=C6C=1N2)=C5C)C(CC)=C4C)=C(C=C)C=3C
InChiKey: DSBPKOBGFPQJGR-NXMWDSTHSA-N
InChi: InChI=1S/C34H34N4O5/c1-8-19-15(3)22-12-24-17(5)21(10-11-28(39)42-7)31(37-24)30-32-29(33(40)43-34(30)41)18(6)25(38-32)14-27-20(9-2)16(4)23(36-27)13-26(19)35-22/h8,12-14,17,35,37,41H,1,9-11H2,2-7H3/b23-13-,24-12-,25-14-/t17-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Purpurin 18 methyl ester (1-5 μg/mL; 24 h) has no cytotoxicity in dark in HepG-2 cells. Purpurin 18 methyl ester (1-5 μg/mL; 24 h) decreases the viability of HepG-2 cells in a concentration-dependent manner with irradiation for 10 min. Purpurin 18 methyl ester (0-24 h) is released from GO- Purpurin 18 methyl ester (Pu18) composite, with rates of 47%, 22% and 30% in weak acidic condition (pH 5.6), neutral environment (pH 7.4) and weak alkali condition (pH 8.9) for 24 h, respectively.
Products are for research use only. Not for human use.
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