Description
BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 free base blocks MM-induced NET formation and delays progression of MM in a syngeneic mouse model.
Product information
CAS Number: 1550371-22-6
Molecular Weight: 472.58
Formula: C27H32N6O2
Chemical Name: (3R,6S)-1-{2-[1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-7-methoxy-1-methyl-1H-1,3-benzodiazole-5-carbonyl}-6-methylpiperidin-3-amine
Smiles: CN1C2C(=CC(=CC=2OC)C(=O)N2C[C@H](N)CC[C@@H]2C)N=C1C1=CC2=CC=CN=C2N1CC1CC1
InChiKey: PXJXCBYHGJEEJH-OXJNMPFZSA-N
InChi: InChI=1S/C27H32N6O2/c1-16-6-9-20(28)15-32(16)27(34)19-11-21-24(23(13-19)35-3)31(2)26(30-21)22-12-18-5-4-10-29-25(18)33(22)14-17-7-8-17/h4-5,10-13,16-17,20H,6-9,14-15,28H2,1-3H3/t16-,20+/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 250 mg/mL (529.01 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
BMS-P5 blocks calcium ionophore-induced citrullination of histone H3. BMS-P5 is also able to inhibit formation of NETs induced by primary MM cells isolated from the BM of patients with MM.
In Vivo:
BMS-P5 (50 mg/kg, oral gavage) significantly improves survival of MM-bearing mice. BMS-P5 (50 mg/kg, oral gavage) may attenuate the presence of pro-tumorigenic proteins in the tumor microenvironment, and thus delay tumor progression.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.