BAY-6035


Catalog No. Size PriceQuantity
M26059-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

BAY-6035 is a potent, selective and substrate-competitive inhibitor of SMYD3. BAY-6035 inhibits methylation of MEKK2 peptide with an IC50 of 88 nM.

Product information

CAS Number: 2247890-13-5

Molecular Weight: 396.48

Formula: C22H28N4O3

Chemical Name: (2S)-1-{3-azabicyclo[3.1.0]hexane-3-carbonyl}-N-(2-cyclopropylethyl)-2-methyl-4-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-7-carboxamide

Smiles: C[C@H]1CC(=O)NC2=CC(=CC=C2N1C(=O)N1CC2CC2C1)C(=O)NCCC1CC1

InChiKey: CKFRXCBNKKOFGO-IGEOTXOUSA-N

InChi: InChI=1S/C22H28N4O3/c1-13-8-20(27)24-18-10-15(21(28)23-7-6-14-2-3-14)4-5-19(18)26(13)22(29)25-11-16-9-17(16)12-25/h4-5,10,13-14,16-17H,2-3,6-9,11-12H2,1H3,(H,23,28)(H,24,27)/t13-,16?,17?/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

BAY-6035 inhibits in vitro methylation of MEKK2 peptide with an IC50 of 88 nM and has more than 100-fold selectivity over other histone methyltransferases. BAY-6035 inhibits the methylation of MEKK2 in cells with an IC50 of 70 nM.

Products are for research use only. Not for human use.

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