Description
NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM).
Product information
CAS Number: 2250019-95-3
Molecular Weight: 465.90
Formula: C22H23ClF3N5O
Chemical Name: (3S)-3-{[13-chloro-2-(2,2-difluoroethyl)-6-fluoro-2,9-diazatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-10-ylidene]amino}-N,N-dimethylpyrrolidine-1-carboxamide
Smiles: CN(C)C(=O)N1CC[C@@H](C1)N=C1NC2=CC(F)=CC=C2N(CC(F)F)C2=CC=C(Cl)C=C21
InChiKey: RVHZFZVJXGIAJF-HNNXBMFYSA-N
InChi: InChI=1S/C22H23ClF3N5O/c1-29(2)22(32)30-8-7-15(11-30)27-21-16-9-13(23)3-5-18(16)31(12-20(25)26)19-6-4-14(24)10-17(19)28-21/h3-6,9-10,15,20H,7-8,11-12H2,1-2H3,(H,27,28)/t15-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
NVS-PAK1-1 potently inhibits autophosphorylation of PAK1 (S144) at 0.25 µM in the Su86.86 cell line and MEK S289 phosphorylation with an IC50=0.21 µM in Su86.86 cells in which PAK2 is downregulated.
Products are for research use only. Not for human use.
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