Chymase-IN-1


Catalog No. Size PriceQuantity
M26109-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.

Product information

CAS Number: 862090-74-2

Molecular Weight: 431.83

Formula: C20H15ClNO4PS

Chemical Name: [(5-chloro-1-benzothiophen-3-yl)[(naphthalen-2-yl)carbamoyl]methyl]phosphonic acid

Smiles: OP(O)(=O)C(C1=CSC2=CC=C(Cl)C=C12)C(=O)NC1=CC2=CC=CC=C2C=C1

InChiKey: HUJXISJLAPAFBO-UHFFFAOYSA-N

InChi: InChI=1S/C20H15ClNO4PS/c21-14-6-8-18-16(10-14)17(11-28-18)19(27(24,25)26)20(23)22-15-7-5-12-3-1-2-4-13(12)9-15/h1-11,19H,(H,22,23)(H2,24,25,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Chymase-IN-1 (compound 5f) is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM. Results demonstrate that Chymase-IN-1 has a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM.

In Vivo:

Chymase-IN-1 exhibits low oral bioavailability in rats (F=3%; oral t1/2=1.8 h).

Products are for research use only. Not for human use.

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