EAD1


Catalog No. Size PriceQuantity
M26141-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

EAD1 is a potent autophagy inhibitor with antiproliferative activity in lung and pancreatic cancer cells. EAD1 also induces apoptosis.

Product information

CAS Number: 1644388-26-0

Molecular Weight: 484.42

Formula: C24H27Cl2N7

Chemical Name: 7-chloro-N-[2-({2-[({1-[(4-chlorophenyl)methyl]-1H-1,2,3-triazol-4-yl}methyl)amino]ethyl}(methyl)amino)ethyl]quinolin-4-amine

Smiles: CN(CCNC1=CC=NC2=CC(Cl)=CC=C12)CCNCC1=CN(CC2C=CC(Cl)=CC=2)N=N1

InChiKey: NUQMXKCBSUXVTG-UHFFFAOYSA-N

InChi: InChI=1S/C24H27Cl2N7/c1-32(13-11-29-23-8-9-28-24-14-20(26)6-7-22(23)24)12-10-27-15-21-17-33(31-30-21)16-18-2-4-19(25)5-3-18/h2-9,14,17,27H,10-13,15-16H2,1H3,(H,28,29)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

EAD1 (0-200 μM; 72 hours) has antiproliferative activity against human cancer cell lines. EAD1 (5-75 μM; 24 hours) induces apoptosis in the H460 cells in a concentration-dependent manner. EAD1 (1-25 μM; 24 hour) increases the punctate LC3 signal in H460 cells.

Products are for research use only. Not for human use.

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