Description
OD36 is a RIPK2 inhibitor with an IC50 of 5.3 nM. OD36 is a macrocyclic inhibitor with potent binding to the ALK2 kinase ATP pocket. OD36 shows ALK2-directed activity with KDs of 37 nM.
Product information
CAS Number: 1638644-62-8
Molecular Weight: 330.77
Formula: C16H15ClN4O2
Chemical Name: 4-chloro-7,10-dioxa-13,17,18,21-tetraazatetracyclo[12.5.2.1²,⁶.0¹⁷,²⁰]docosa-1(20),2,4,6(22),14(21),15,18-heptaene
Smiles: ClC1C=C2C=C(C=1)OCCOCCNC1C=CN3N=CC2=C3N=1
InChiKey: KTSDBMVHAKWDRK-UHFFFAOYSA-N
InChi: InChI=1S/C16H15ClN4O2/c17-12-7-11-8-13(9-12)23-6-5-22-4-2-18-15-1-3-21-16(20-15)14(11)10-19-21/h1,3,7-10H,2,4-6H2,(H,18,20)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
OD36 also inhibits ALK2 and ALK2 R206H with IC50s of 47 and 22 nM, respevtively. OD36 shows activity against ALK1 with a KD of 90 nM. OD36 potently antagonize mutant ALK2 signaling and osteogenic differentiation. OD36 (0.1-1 μM) efficiently inhibits BMP-6 (50 ng/mL)-induced p-Smad1/5 in KS483 cells. Preincubation of fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs) with OD36 (0.5 μM) completely prevents the activation of Smad1/5 and gene targets ID-1 and ID-3 in response to activin A.
Products are for research use only. Not for human use.
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