PM226


Catalog No. Size PriceQuantity
M26250-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

PM226 is a selective cannabinoid CB2R agonist (Ki (CB2R)=13 nM; EC50 (CB2R)=39 nM; Ki (CB1R) >40 μM;) with neuroprotective properties in vitro and vivo.

Product information

CAS Number: 1949726-13-9

Molecular Weight: 357.49

Formula: C22H31NO3

Chemical Name: 9-methoxy-4,4-dimethyl-7-(2-methyloctan-2-yl)-4H-chromeno[3,4-d][1,2]oxazole

Smiles: COC1=CC(=CC2OC(C)(C)C3C=NOC=3C=21)C(C)(C)CCCCCC

InChiKey: VFWIRWAAMNBBFG-UHFFFAOYSA-N

InChi: InChI=1S/C22H31NO3/c1-7-8-9-10-11-21(2,3)15-12-17(24-6)19-18(13-15)25-22(4,5)16-14-23-26-20(16)19/h12-14H,7-11H2,1-6H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PM226 binds selectively to CB2 receptor with an affinity in the nanomolar range (Ki=12.8±2.4 nM). PM226 has negligible affinity for the CB1 receptor (Ki >40000 nM) and no activity at the GPR55. PM226 was also evaluated in GTPγS binding assays specific to the CB2 receptor showing agonist activity (EC50=38.67±6.70 nM).

In Vivo:

PM226 (0.1, 1 and 10 mg/kg; administered i.p.) administration decreases the volume of the striatal lesion caused by Malonate.

Products are for research use only. Not for human use.

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