Description
BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC50 of 22 nM.
Product information
CAS Number: 1352416-78-4
Molecular Weight: 421.35
Formula: C19H15F4N5O2
Chemical Name: N-{3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-cyanopyridine-2-carboxamide
Smiles: C[C@@]1(N=C(N)CO[C@H]1C(F)(F)F)C1=CC(=CC=C1F)NC(=O)C1=CC=C(C=N1)C#N
InChiKey: YCNKUIFVRZSRNL-QZTJIDSGSA-N
InChi: InChI=1S/C19H15F4N5O2/c1-18(17(19(21,22)23)30-9-15(25)28-18)12-6-11(3-4-13(12)20)27-16(29)14-5-2-10(7-24)8-26-14/h2-6,8,17H,9H2,1H3,(H2,25,28)(H,27,29)/t17-,18-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
BACE1-IN-2 (Compound 3) is 10-fold more potent toward BACE1 than BACE2, inhibition of which may lead to hair depigmentation. BACE1-IN-2 inhibits hAβ42 cell with an IC50 of 6.0 nM.
Products are for research use only. Not for human use.
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