GNE-0439


Catalog No. Size PriceQuantity
M26312-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

GNE-0439 is a novel Nav1.7-selective inhibitor with IC50 of 0.34 uM and inhibits Nav1.5 with an IC50 of 38.3 μM. GNE-0439 inhibits mutant N1742K channels (IC50=0.37 uM) in membrane potential assays. GNE-0439 possesses a carboxylic acid group, binds outside of the channel pore, and is unique compared with known selective VSD4 binders.

Product information

CAS Number: 1241902-40-8

Molecular Weight: 345.48

Formula: C21H31NO3

Chemical Name: (2S)-3-methyl-2-{[4-(4-propylcyclohexyl)phenyl]formamido}butanoic acid

Smiles: CC(C)[C@H](NC(=O)C1=CC=C(C=C1)C1CCC(CCC)CC1)C(O)=O

InChiKey: SKMKUWKJBZSEJH-RJYAGPCLSA-N

InChi: InChI=1S/C21H31NO3/c1-4-5-15-6-8-16(9-7-15)17-10-12-18(13-11-17)20(23)22-19(14(2)3)21(24)25/h10-16,19H,4-9H2,1-3H3,(H,22,23)(H,24,25)/t15?,16?,19-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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