2-Methylcitric acid


Catalog No. Size PriceQuantity
M26314-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

2-Methylcitric acid (Methylcitric acid) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate.

Product information

CAS Number: 6061-96-7

Molecular Weight: 206.15

Formula: C7H10O7

Chemical Name: 2-hydroxy-1-methylpropane-1,2,3-tricarboxylic acid

Smiles: CC(C(O)=O)C(O)(CC(O)=O)C(O)=O

InChiKey: YNOXCRMFGMSKIJ-UHFFFAOYSA-N

InChi: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (485.08 mM; Need ultrasonic). H2O : 100 mg/mL (485.08 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

2-Methylcitric acid (Methylcitric acid) impairs glutamate metabolism and induces permeability transition in brain mitochondria. 2-Methylcitric acid inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM. 2-Methylcitric acid (1-3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca2+-loaded mitochondria supported by different substrates. 2-Methylcitric acid behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis. 2-Methylcitric acid does not significantly impair mitochondrial glutamate transport. 2-Methylcitric acid does not significantly impair glutamate mitochondrial transport in liver mitochondria.

Products are for research use only. Not for human use.

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