Description
Bromo-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Product information
CAS Number: 2148295-98-9
Molecular Weight: 426.26
Formula: C15H24BrNO8
Chemical Name: 2,5-dioxopyrrolidin-1-yl 1-bromo-3,6,9,12-tetraoxapentadecan-15-oate
Smiles: O=C(CCOCCOCCOCCOCCBr)ON1C(=O)CCC1=O
InChiKey: GIZQHAGVFHQMFN-UHFFFAOYSA-N
InChi: InChI=1S/C15H24BrNO8/c16-4-6-22-8-10-24-12-11-23-9-7-21-5-3-15(20)25-17-13(18)1-2-14(17)19/h1-12H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Products are for research use only. Not for human use.
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