Description
Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Product information
CAS Number: 1343476-41-4
Molecular Weight: 435.42
Formula: C18H29NO11
Chemical Name: 19-[(2,5-dioxopyrrolidin-1-yl)oxy]-19-oxo-4,7,10,13,16-pentaoxanonadecanoic acid
Smiles: OC(=O)CCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O
InChiKey: QMACGMMKGUAJOY-UHFFFAOYSA-N
InChi: InChI=1S/C18H29NO11/c20-15-1-2-16(21)19(15)30-18(24)4-6-26-8-10-28-12-14-29-13-11-27-9-7-25-5-3-17(22)23/h1-14H2,(H,22,23)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Products are for research use only. Not for human use.
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