Description
Alstonine is a major indole alkaloid compound of a plant-based remedy. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties.
Product information
CAS Number: 642-18-2
Molecular Weight: 348.40
Formula: C21H20N2O3
Chemical Name: methyl (15S,16S,20S)-16-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹⁰.0⁴,⁹.0¹⁵,²⁰]henicosa-1,3,5,7,9,11,18-heptaene-19-carboxylate
Smiles: C[C@@H]1OC=C([C@H]2CC3=C4N=C5C=CC=CC5=C4C=CN3C[C@@H]12)C(=O)OC
InChiKey: WYTGDNHDOZPMIW-RCBQFDQVSA-N
InChi: InChI=1S/C21H20N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-8,11-12,15-16H,9-10H2,1-2H3/t12-,15-,16-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Alstonine has the capacity to distinguish cancer DNA from healthy tissue DNA; it inhibits DNA in vitro synthesis when DNA from different cancerous tissues or cells is used as template. Practically without effects on DNA from healthy tissues.
In Vivo:
In mice models Alstonine shows a clear, dose-dependent, potent antipsychotic profile. Alstonine (i.p.) prevents amphetamine-induced lethality, with active doses within the range of 0.5-2.0 mg/kg. Alstonine (0.1, 0.5 and 1.0 mg/kg) prevents MK-801 induced hyperlocomotion. Because Alstonine partially reverses MK-801-induced increase in locomotion both at the hole-board and locomotor activity cages. Alstonine successfully treats a relatively important proportion of BALB/C mice inoculated with transplantable YC8 lymphoma ascites cells as well as Swiss mice bearing Ehrlich ascites carcinoma cells.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.
