PluriSIn #2


Catalog No. Size PriceQuantity
M27131-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs).

Product information

CAS Number: 56563-17-8

Molecular Weight: 249.20

Formula: C11H8FN3O3

Chemical Name: 5-fluoro-2,4-dioxo-N-phenyl-1,2,3,4-tetrahydropyrimidine-1-carboxamide

Smiles: O=C1NC(=O)C(F)=CN1C(=O)NC1C=CC=CC=1

InChiKey: PXXNTSRWKSCFCK-UHFFFAOYSA-N

InChi: InChI=1S/C11H8FN3O3/c12-8-6-15(11(18)14-9(8)16)10(17)13-7-4-2-1-3-5-7/h1-6H,(H,13,17)(H,14,16,18)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 5 mg/mL (20.06 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PluriSIn #2 (20 µM; 12 hours) treatment reduces TOP2A expression at the protein level. A 24h exposure of PluriSIn #2 (20 µM) is sufficient to induce massive cell death in hPSCs, but doesn’t affect the viability of various other cell types derived from them.

Products are for research use only. Not for human use.

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