Description
Direct Violet 1, an azo dye, is a textile dye. Direct Violet 1 is also the protein-protein interaction (PPI) between the SARS-CoV-2 spike protein and ACE2 inhibitor with IC50s of 1.47-2.63 µM.
Product information
CAS Number: 2586-60-9
Molecular Weight: 728.66
Formula: C32H22N6Na2O8S2
Chemical Name: disodium 6-amino-5-(2-{4'-[2-(2-amino-8-hydroxy-6-sulfonatonaphthalen-1-yl)diazen-1-yl]-[1,1'-biphenyl]-4-yl}diazen-1-yl)-4-hydroxynaphthalene-2-sulfonate
Smiles: [Na+].[Na+].NC1C=CC2=CC(=CC(O)=C2C=1N=NC1C=CC(=CC=1)C1C=CC(=CC=1)N=NC1=C2C(C=C(C=C2O)S([O-])(=O)=O)=CC=C1N)S([O-])(=O)=O
InChiKey: VDRKHPFIMDTBNX-HKXUKFGYSA-L
InChi: InChI=1S/C32H24N6O8S2.2Na/c33-25-11-5-19-13-23(47(41,42)43)15-27(39)29(19)31(25)37-35-21-7-1-17(2-8-21)18-3-9-22(10-4-18)36-38-32-26(34)12-6-20-14-24(48(44,45)46)16-28(40)30(20)32;;/h1-16,39-40H,33-34H2,(H,41,42,43)(H,44,45,46);;/q;2*+1/p-2/b37-35+,38-36+;;
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: H2O : 62.5 mg/mL (85.77 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Direct Violet 1 inhibits SARS-CoV-2-S-RBD binding to human ACE2, inhibits SARS-CoV-S1S2 binding to ACE2, and inhibits TNF-R1 binding to TNFα with IC50 values of 1.47 µM, 2.63 µM, and 2.11 µM, respectively. Direct Violet 1 inhibits SARS-CoV-2 pseudovirus entry into hACE2 expressing host cells in a concentration-dependent manner with an IC50 of 35.8 µM.
Products are for research use only. Not for human use.
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