Description
AZ-Dyrk1B-33 is a potent and selective Dyrk1B kinase inhibitor, with an IC50 of 7 nM.
Product information
CAS Number: 1679330-37-0
Molecular Weight: 300.36
Formula: C19H16N4
Chemical Name: 4-{1-benzyl-1H-pyrrolo[2,3-c]pyridin-3-yl}-2-methylpyrimidine
Smiles: CC1=NC(=CC=N1)C1=CN(CC2C=CC=CC=2)C2=CN=CC=C21
InChiKey: CZCUSHJQJWKYTD-UHFFFAOYSA-N
InChi: InChI=1S/C19H16N4/c1-14-21-10-8-18(22-14)17-13-23(12-15-5-3-2-4-6-15)19-11-20-9-7-16(17)19/h2-11,13H,12H2,1H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 125 mg/mL (416.17 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
AZ-Dyrk1B-33 shows inhibition of phosphorylation of Dyrk pS421 in cells with an IC50 of 0.192 μM. AZ-Dyrk1B-33 shows no effect in sensitization.
Products are for research use only. Not for human use.
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