YAP/TAZ inhibitor-1

YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor extracted from patent WO2017058716A1, Compound 1, has an IC50 of <0.100 μΜ in firefly luciferase assay.

Product information

CAS Number: 2093565-23-0

Molecular Weight: 621.81

Formula: C33H39N3O5S2

Chemical Name: N-[(9E)-2-[(4,4-dimethylcyclohexyl)sulfonyl]-7-{[4-(1-phenylethyl)piperazin-1-yl]sulfonyl}-9H-fluoren-9-ylidene]hydroxylamine

Smiles: CC(C1C=CC=CC=1)N1CCN(CC1)S(=O)(=O)C1=CC2/C(=N/O)/C3=CC(=CC=C3C=2C=C1)S(=O)(=O)C1CCC(C)(C)CC1

InChiKey: MYVLNSCWZUAUMQ-NWBJSICCSA-N

InChi: InChI=1S/C33H39N3O5S2/c1-23(24-7-5-4-6-8-24)35-17-19-36(20-18-35)43(40,41)27-10-12-29-28-11-9-26(21-30(28)32(34-37)31(29)22-27)42(38,39)25-13-15-33(2,3)16-14-25/h4-12,21-23,25,37H,13-20H2,1-3H3/b34-32+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 62.5 mg/mL (100.51 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

YAP and TAZ are transcriptional co-activators of the Hippo pathway network and regulate cell proliferation, migration, and apoptosis. YAP/TAZ inhibitor-1 is an inhibitor of transcriptional coactivator with PDZ binding motif/Yes- associated protein transcriptional coactivator (TAZ/YAP).

Products are for research use only. Not for human use.