Description
AHN 1-055 hydrochloride is a dopamine uptake inhibitor, with an IC50 of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT) and may serve as leads for the development of agentia to treat cocaine abuse.
Product information
CAS Number: 202646-03-5
Molecular Weight: 379.87
Formula: C21H24ClF2NO
Chemical Name: 3-[bis(4-fluorophenyl)methoxy]-8-methyl-8-azabicyclo[3.2.1]octane hydrochloride
Smiles: Cl.CN1C2CC(CC1CC2)OC(C1C=CC(F)=CC=1)C1C=CC(F)=CC=1
InChiKey: YOORVSGDAHWVMC-UHFFFAOYSA-N
InChi: InChI=1S/C21H23F2NO.ClH/c1-24-18-10-11-19(24)13-20(12-18)25-21(14-2-6-16(22)7-3-14)15-4-8-17(23)9-5-15;/h2-9,18-21H,10-13H2,1H3;1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 125 mg/mL (329.06 mM; Need ultrasonic). H2O : 33.33 mg/mL (87.74 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
AHN 1-055 (5 mg/kg; i.v.) inhibits the uptaking of brain dopamine with an IC50 of 311.8 ng/ml in vivo. AHN 1-055 (10 mg/kg; i.v.) exhibits Cmax of 1.48 mg/L and terminal elimination half-lives of 7.69 h due to 1.8L/h/kg plasma clearance combined with 18.7 L/kg volumes of distribution.
Products are for research use only. Not for human use.
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