Description
Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation.
Product information
CAS Number: 916888-47-6
Molecular Weight: 376.49
Formula: C22H32O5
Chemical Name: (4S,5Z,7E,9E,11R,13Z,15E,17S,19Z)-4,11,17-trihydroxydocosa-5,7,9,13,15,19-hexaenoic acid
Smiles: CC/C=C\C[C@H](O)/C=C/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCC(O)=O
InChiKey: QBTJOLCUKWLTIC-UZAFJXHNSA-N
InChi: InChI=1S/C22H32O5/c1-2-3-7-12-19(23)14-10-6-11-15-20(24)13-8-4-5-9-16-21(25)17-18-22(26)27/h3-11,13-14,16,19-21,23-25H,2,12,15,17-18H2,1H3,(H,26,27)/b5-4+,7-3-,11-6-,13-8+,14-10+,16-9-/t19-,20-,21+/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
RvD3 (RvD3; 10 nM) significantly inhibits tumor necrosis factor-α–induced NF-κB activation in A549 epithelial cells.
In Vivo:
Resolvin D3 (RvD3; 100 ng/100 µl; IP; daily for 6 days) alleviates arthritis progression, reduces edema and limits leukocyte numbers in murine K/BxN-serum induced arthritis.
Products are for research use only. Not for human use.
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