Description
DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM.
Product information
CAS Number: 2146177-09-3
Molecular Weight: 311.34
Formula: C16H17N5O2
Chemical Name: methyl N-[6-(3-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-1H-indazol-4-yl]carbamate
Smiles: CC1NN=C(C2CC2)C=1C1C=C2NN=CC2=C(C=1)NC(=O)OC
InChiKey: QTYLFQMDDFBRTJ-UHFFFAOYSA-N
InChi: InChI=1S/C16H17N5O2/c1-8-14(15(21-19-8)9-3-4-9)10-5-12(18-16(22)23-2)11-7-17-20-13(11)6-10/h5-7,9H,3-4H2,1-2H3,(H,17,20)(H,18,22)(H,19,21)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
DS28120313 (deliver orally; 30 mg/kg; 30 min before IL-6 administration) inhibits hepcidin production and reduces the blood hepcidin level in IL-6 induced acute inflammatory C57BL/6 mouse model.
Products are for research use only. Not for human use.
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