JHU395


Catalog No. Size PriceQuantity
M27389-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) prodrug. JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST.

Product information

CAS Number: 2079938-92-2

Molecular Weight: 447.48

Formula: C22H29N3O7

Chemical Name: propan-2-yl (2S)-6-diazo-2-[({[(2,2-dimethylpropanoyl)oxy](phenyl)methoxy}carbonyl)amino]-5-oxohexanoate

Smiles: CC(C)OC(=O)[C@H](CCC(=O)C=[N+]=[N-])NC(=O)OC(OC(=O)C(C)(C)C)C1=CC=CC=C1

InChiKey: QQIBFRQTTLIECS-KKFHFHRHSA-N

InChi: InChI=1S/C22H29N3O7/c1-14(2)30-18(27)17(12-11-16(26)13-24-23)25-21(29)32-19(15-9-7-6-8-10-15)31-20(28)22(3,4)5/h6-10,13-14,17,19H,11-12H2,1-5H3,(H,25,29)/t17-,19?/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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