Description
BMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively.
Product information
CAS Number: 1679371-59-5
Molecular Weight: 369.46
Formula: C21H27N3O3
Chemical Name: N-(8-{[(2S)-2-amino-2,4-dimethylpentyl]oxy}-5H-chromeno[3,4-c]pyridin-2-yl)acetamide
Smiles: CC(=O)NC1=CC2C3=CC=C(C=C3OCC=2C=N1)OC[C@@](C)(N)CC(C)C
InChiKey: OQMXEZIHZRSBOY-NRFANRHFSA-N
InChi: InChI=1S/C21H27N3O3/c1-13(2)9-21(4,22)12-27-16-5-6-17-18-8-20(24-14(3)25)23-10-15(18)11-26-19(17)7-16/h5-8,10,13H,9,11-12,22H2,1-4H3,(H,23,24,25)/t21-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
BMT-124110 shows a cellular IC50 of 3.2±1.4 nM for AAK1.
In Vivo:
BMT-124110 is added directly onto the spinal corevd by microiontophoresis, leading to reduction in windup-induced activity in 10 of 14 animals.
Products are for research use only. Not for human use.
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