SLLN-15


Catalog No. Size PriceQuantity
M27682-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SLLN-15 is an oral active, selective and potent enhancer of autophagy that activates cytostatic macroautophagy/autophagy in triple-negative breast cancer (TNBC).

Product information

CAS Number: 2403650-93-9

Molecular Weight: 507.35

Formula: C19H23N7Se2

Chemical Name: N6-[(3S)-selenolan-3-yl]-N2-[4-(selenomorpholin-4-yl)phenyl]-7H-purine-2,6-diamine

Smiles: C1[Se]CC[C@@H]1NC1=NC(NC2C=CC(=CC=2)N2CC[Se]CC2)=NC2N=CNC1=2

InChiKey: KUGJLOYHZKIOSI-AWEZNQCLSA-N

InChi: InChI=1S/C19H23N7Se2/c1-3-15(26-6-9-27-10-7-26)4-2-13(1)23-19-24-17-16(20-12-21-17)18(25-19)22-14-5-8-28-11-14/h1-4,12,14H,5-11H2,(H3,20,21,22,23,24,25)/t14-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

SLLN-15 (0, 1, 5, 10, 25 μM) treatment for 24 h markedly decreases overall cell viability of breast cancer cells in a dose-dependent manner. SLLN-15 (100 nM and 1000 nM, 7 days) is able to equally inhibit the colony formation abilities of several breast cancer cell lines. Overall, SLLN-15 induces a dose-dependent anti-proliferative activity in the TNBC cell lines MDA-MB-231 and BT-20 via induction of autophagy and autophagic flux. This induction is associated with a selective inhibition of AKT-MTOR signaling.

In Vivo:

SLLN-15 (30mg/kg, PO, 3 times a week) not only inhibits the growth of TNBC in animal model, but also TNBC cell progression to metastases. Overall, oral SLLN-15 reveals a potent anticancer and anti-metastatic activity in mice bearing TNBC.

Products are for research use only. Not for human use.

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