Description
BLM-IN-1 (compound 29) is an effective Bloom syndrome protein (BLM) inhibitor, with a strong BLM binding KD of 1.81 μM and an IC50 of 0.95 μM for BLM. Induces DNA damage response, as well as apoptosis and proliferation arrest in cancer cells.
Product information
CAS Number: 2056014-40-3
Molecular Weight: 462.60
Formula: C28H35FN4O
Chemical Name: (3E)-6-{[3-(diethylamino)propyl]amino}-7-fluoro-3-{[4-(propan-2-yl)phenyl]methylidene}-1H,2H,3H,9H-pyrrolo[2,1-b]quinazolin-9-one
Smiles: CC(C)C1C=CC(/C=C2\CCN3C(=O)C4=CC(F)=C(C=C4N=C3\2)NCCCN(CC)CC)=CC=1
InChiKey: GZSNGNPLURZQGM-CJLVFECKSA-N
InChi: InChI=1S/C28H35FN4O/c1-5-32(6-2)14-7-13-30-26-18-25-23(17-24(26)29)28(34)33-15-12-22(27(33)31-25)16-20-8-10-21(11-9-20)19(3)4/h8-11,16-19,30H,5-7,12-15H2,1-4H3/b22-16+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 8.33 mg/mL (18.01 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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