IV-23


Catalog No. Size PriceQuantity
M27781-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

IV-23 (Compound 20) is a potent Noxa mediated apoptosis inducer, and it is a promising anticancer agent with potential. IV-23 inhibits cell growths in vitro and in vivo, reduces colony formation, arrests cell cycle at M phase, and induces esophageal squamous cell carcinoma (ESCC).

Product information

CAS Number: 2326007-49-0

Molecular Weight: 392.24

Formula: C18H18BrNO4

Chemical Name: 5-bromo-1-(3,4,5-trimethoxybenzoyl)-2,3-dihydro-1H-indole

Smiles: COC1C=C(C=C(OC)C=1OC)C(=O)N1CCC2=CC(Br)=CC=C12

InChiKey: WQEJDTDMFXKTOT-UHFFFAOYSA-N

InChi: InChI=1S/C18H18BrNO4/c1-22-15-9-12(10-16(23-2)17(15)24-3)18(21)20-7-6-11-8-13(19)4-5-14(11)20/h4-5,8-10H,6-7H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

IV-23 (Compound 20) shows a strong inhibition against the ESCCs in a concentration depend manner, the IC50 values against the Kyse30 and Kyse450 cell lines were all less than 2 μM, presented in a dose-dependent manner. IV-23 triggeres caspases related apoptosis in ESCC cells. IV-23 induces G2/M phase arrest.

Products are for research use only. Not for human use.

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