Description
Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity.
Product information
CAS Number: 802918-57-6
Molecular Weight: 482.44
Formula: C25H22O10
Chemical Name: (2R,3R)-3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one
Smiles: COC1=CC(=CC=C1O)C1OC2=CC(=CC=C2OC1CO)[C@H]1OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O
InChiKey: SEBFKMXJBCUCAI-DBMPWETRSA-N
InChi: InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20?,23-,24?,25+/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Silybin (0-200 mM; for 72 hours) has growth inhibition in a time- and dose-dependent manner. Silybin (68 μM; for 72 hours) induces apoptosis and increases the cells in G1-phase of ~22%. Silybin (68 μM; for 72 hours) induces AKT activity inhibition.
In Vivo:
Silybin (50, 100 mg/kg/day; given intragastrically for the last 4 weeks) significantly lowers both serum and hepatic lipid accumulation.
Products are for research use only. Not for human use.
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