EACC


Catalog No. Size PriceQuantity
M27883-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion.

Product information

CAS Number: 864941-31-1

Molecular Weight: 369.37

Formula: C13H11N3O6S2

Chemical Name: ethyl N-[2-(5-nitrothiophene-2-amido)thiophene-3-carbonyl]carbamate

Smiles: CCOC(=O)NC(=O)C1C=CSC=1NC(=O)C1=CC=C(S1)[N+]([O-])=O

InChiKey: ISLJZDYAPAUORR-UHFFFAOYSA-N

InChi: InChI=1S/C13H11N3O6S2/c1-2-22-13(19)15-10(17)7-5-6-23-12(7)14-11(18)8-3-4-9(24-8)16(20)21/h3-6H,2H2,1H3,(H,14,18)(H,15,17,19)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 16.88 mg/mL (45.70 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

EACC blocks autophagosome-lysosome fusion but does not affect endo-lysosomal function. EACC inhibits autophagy by preventing SNARE Stx17 loading on autophagosomes. EACC does not affect RABs, tethers, and lysosomal SNARE but prevents their interaction with LC3 and Stx17.

Products are for research use only. Not for human use.

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