DDR1-IN-5


Catalog No. Size PriceQuantity
M27954-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

DDR1-IN-5 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC50 of 7.36 nM. DDR1-IN-5 inhibits auto-phosphorylation DDR1b (Y513) with an IC50 of 4.1 nM. DDR1-IN-5 has anti-cancer activity.

Product information

CAS Number: 2416022-90-5

Molecular Weight: 434.37

Formula: C22H13F3N6O

Chemical Name: 7-(2-{imidazo[1,2-b]pyridazin-3-yl}ethynyl)-6-methyl-N-[5-(trifluoromethyl)pyridin-3-yl]-1,2-benzoxazol-3-amine

Smiles: CC1=CC=C2C(ON=C2NC2C=NC=C(C=2)C(F)(F)F)=C1C#CC1=CN=C2C=CC=NN21

InChiKey: LGHRUPKASNQBFS-UHFFFAOYSA-N

InChi: InChI=1S/C22H13F3N6O/c1-13-4-6-18-20(17(13)7-5-16-12-27-19-3-2-8-28-31(16)19)32-30-21(18)29-15-9-14(10-26-11-15)22(23,24)25/h2-4,6,8-12H,1H3,(H,29,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

DDR1-IN-5 (compound 121; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC50=62 nM). DDR1-IN-5 (72 hours) has cytotoxicity in LX-2 cells (CC50>40 μM).

Products are for research use only. Not for human use.

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