Description
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB.
Product information
CAS Number: 644-78-0
Molecular Weight: 224.25
Formula: C15H12O2
Chemical Name: (2E)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one
Smiles: OC1=CC=CC=C1/C=C/C(=O)C1C=CC=CC=1
InChiKey: UDOOPSJCRMKSGL-ZHACJKMWSA-N
InChi: InChI=1S/C15H12O2/c16-14-9-5-4-8-13(14)10-11-15(17)12-6-2-1-3-7-12/h1-11,16H/b11-10+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells. 2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner.
Products are for research use only. Not for human use.
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